The MF59 Adjuvant – Related Articles « ByREV

Related Articles about the MF59 immunologic adjuvant

Trial of 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine
http://content.nejm.org/cgi/content/full/NEJMoa0907650
Background The 2009 pandemic influenza A (H1N1) virus has emerged to cause the first pandemic of the 21st century. Development of effective vaccines is a public health priority. Methods We conducted a single-center study, involving 176 adults, 18 to 50 years of age, to test the monovalent influenza A/California/2009 (H1N1) surface-antigen vaccine, in both MF59-adjuvanted and nonadjuvanted forms.

Novartis Investigational Adjuvanted (MF59) Pre-pandemic Avian Influenza Vaccine Aflunov® Shows Long Lasting, cross-protective Immune Response
http://www.medicalnewstoday.com/articles/148563.php
A study published this week in the Proceedings of the National Academy of Sciences of the United States of America shows that Aflunov®, the Novartis investigational pre-pandemic avian influenza vaccine formulated with Novartis’ proprietary MF59® adjuvant, can elicit a broadly cross-reactive immune response covering all known H5N1 antigenic variants, even when that booster dose is administered six years after the initial priming dose.

Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza.
http://www.ncbi.nlm.nih.gov/pubmed/11425416
In 1997, pathogenic avian influenza A/Hong Kong/97 (H5N1) viruses emerged as a pandemic threat to human beings. A non-pathogenic variant, influenza A/Duck/Singapore/97 (H5N3), was identified as a leading vaccine candidate. We did an observer-blind, phase I, randomised trial in healthy volunteers to assess safety, tolerability, and antigenicity of MF59-adjuvanted and non-adjuvanted vaccines.

The MF59 Adjuvant – Serious threat or internet conspiracy rumor?
http://web.mac.com/monotreme1/iWeb/Pandemic%20Influenza%20Information/
There’s been a lot of interest in adjuvants because the early clinical trials with vaccines to H5N1 were very disappointing. These vaccines were relatively poor at stimulating immune responses. Enter MF59. MF59 is a derivative of squalene a naturally occurring substance found in most animals.

N1H1 Swine Vaccine More Dangerous than Flu
http://politicolnews.com/topics/mf-59-toxins/
The outbreak of the supposed pig to man swine flu transfer of 3 viruses that normally would not meet in the natural world has many people puzzled and in shock. How can the CDC, NIH and FDA ignore a thorough investigation of how this flu bug was established? If you do not know the source of how a virus began-how can you find the reason for its very existence let alone treat the problem?

MF59-Adjuvanted H5N1 Vaccine Induces Immunologic Memory and Heterotypic Antibody Responses in Non-Elderly and Elderly Adults
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004384
athogenic avian influenza virus (H5N1) has the potential to cause a major global pandemic in humans. Safe and effective vaccines that induce immunologic memory and broad heterotypic response are needed.